Senior Laboratory Research Scientist

Senior Laboratory Research Scientist Salary for this Role: From £39,950 per annum with benefits, subject to skills and experience

Job Title: Senior Laboratory Research Scientist

Reports to: Natasha Lukoyanova

Closing Date: 18/Nov/2024 23.59 GMT

Job Description: Job title: Senior Laboratory Research Scientist – Cryo-Electron Microscopy

Reporting to: Lead Cryo-Electron Microscopy Specialist

Contract term: This is a full-time permanent position on Crick terms and conditions of employment.

Summary The Francis Crick Institute seeks to recruit a cryo-electron microscopy (cryo-EM) scientist to support single-particle and tomography projects. The Senior Laboratory Research Scientist (SLRS) will be appointed to the Structural Biology Science Technology Platform (SB STP), which supports the Crick in the areas of protein science (expression and purification), biophysics, X-ray crystallography, cryo-EM and related areas. The post holder will help provide a world-class platform to contribute towards key research in collaboration with the Crick scientific community. This is a lab-based position, responsible for driving forward cryo-EM research by providing scientific support and training in single-particle and tomography technologies.

The Crick has a state-of-the-art facility for cryo-electron microscopy and computation, and the post will consolidate excellence in these areas. The STP currently houses two Titan Krios 300kV microscopes equipped with energy filter and direct detector and these are complemented by a Talos Arctica and Glacios 200kV microscope and two 120kV Spirit TEM screening microscopes. There are excellent facilities for computing and expertise in experimental and computational aspects of cryo-EM being developed through the structural biology platform with support from the Crick Scientific Computing STP.

The Role The role of a Senior Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes. Within a Science Technology Platform (STP) - typical activities include:

Providing experimental or technical support to STP users Providing technical expertise/input for the development, refinement and troubleshooting of relevant/novel methodologies. Managing long-term collaborations with STP users. Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings. Writing up findings for publication and completing revisions. Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use. Liaising with Science Operations and attending key quadrant meetings. Writing risk assessments and SOPs and providing safety guidance to lab members. Key responsibilities These include but are not limited to:

Support a range of cryo-EM research activities, including sample preparation. Contribute to management and maintenance of high-end cryo-electron microscopes. Support experimental design including sample preparation and imaging of biological specimens. Provide expertise and support in computational image analysis. Provide training in both experimental and computational aspects of cryo-EM. Experience and Competencies The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial

Essential A higher degree in biological, physical, or engineering sciences; or equivalent relevant experience. Research experience and expertise in electron microscopy or a related technique. Specialist knowledge of cryo-electron microscope operation and high-resolution data collection. Experience in data analysis single particle images and/or tomography data. Experience with field emission gun microscopes and direct electron detectors. Proven track record in structural science. Excellent communication skills within a research environment, building highly effective working relationships with scientists and support staff. Plan time efficiently and be able to work both independently and in a team setting. Desirable PhD in Structural Biology or related areas. Postdoctoral experience in conducting cutting-edge research in cryo-EM. Experience in the use of the cryo-FIB/SEM. Authorship in peer-reviewed publications in internationally recognized scientific journals. Specialist knowledge of cryo-EM reconstruction software. Knowledge of scientific computing including Unix shell scripting, Matlab, Python, programming languages. Flexible working practice. About Us At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources. We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

If you are interested in applying for this role, please apply via our website.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK we will help support your application should you be successful.

Find out what benefits the Crick has to offer: For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion: We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute's success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health.

At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases.

The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.

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