Scientific/Principal Investigator

Site Name: UK - Hertfordshire - Stevenage, Cambridge 300 Technology Square, Heidelberg - Office, USA - Pennsylvania - Upper Providence Posted Date: Nov 20 2024 Scientific/Principal Investigator, Genomic Technologies, Human Genetics and Genomics This position may be based at a GSK R&D site in UK (Stevenage), in USA (Cambridge Tech Square, MA; or Upper Providence, PA), or in Germany (Heidelberg).
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.
We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK We are seeking an innovative scientist to join our team as either Scientific or Principal Investigator in Genomic Technologies .
Within the Human Genetics and Genomics (HGG) department at GSK, the Genomic Technologies group integrates deep and broad expertise in computational and statistical methods and techniques, to enable best-in-class analytical insight and interpretation of genetics and genomics data, impacting GSK drug discovery and development portfolio and pipeline decisions.
Successful candidates will detail in their applications how their personal qualifications, skills and experience make them ideally suited to the specific responsibilities and requirements of the role.
They will join existing teams within Genomic Technologies and will work on projects aligned to current areas of focus, including: Discovery of new causal gene-phenotype links through analysis of large-scale individual level human genetic data and GWAS/xQTL summary statistics.
Expertise in developing and applying innovative statistical approaches at scale to genetic and 'omic datasets to help uncover causal and disease-relevant mechanisms.
Identification of causal genes, disease-relevant mechanisms and cell types, potential drug targets, candidate biomarkers, patient subgroups and disease subtypes, through integration of genetic association data across multiple 'omic and phenotypic layers.
Responsibilities Generating large-scale analysis outputs, and/or implementing state-of-the-art tools for dynamically analysing, interpreting, and visualizing genetic and genomic data.
Evaluating, improving, testing, and developing production implementations of best-in-class methods for analysis of genetics and genomics data, in collaboration with scientists in Data and Predictive Sciences, Biostatistics, or/and AI/ML teams.
Collaborating with partners in applied and translational teams across HGG, in experimental Target Discovery, and in GSK disease area Research Units, to influence portfolio and pipeline decisions.
Staying informed about recent research in the field and considering its potential for application within GSK.
Contributing to a culture of innovation, quality, and willingness to learn and improve.
Why you?
Required Qualifications & Skills: Advanced degree (PhD or equivalent) in a relevant scientific discipline.
Excellent programming skills in R or python, and knowledge of techniques in reproducible research, literate programming, FAIR data principles, or software development.
Experience of evaluating, improving, testing, and/or developing statistical methods for analysis and interpretation of large-scale genetics or genomics data.
Experience with genetic, genomic, epigenomic, or experimental/functional genomic data, and with state-of-the-art methods for data analysis and interpretation.
Strong communication and team-working skills.
Preferred Skills & Experience: Experience with machine learning and/or advanced statistical methods.
Experience working in multidisciplinary teams on complex and impactful projects.
Experience with integrating information across multiple genetic, genomic, epigenomic, or experimental/functional genomic data types.
Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g.
SQL, PySpark, BigQuery, Docker, Nextflow).
Closing Date for Applications - 4th December 2024 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above.
The information that you have provided in your cover letter and CV will be used to assess your application.
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years.
R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery.
We are revolutionising the way we do R&D.
We're uniting science, technology and talent to get ahead of disease together.
Find out more: Our approach to R&D .
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive.
We prevent and treat disease with vaccines, specialty and general medicines.
We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people.
While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive.
We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be.
A place where they can be themselves - feeling welcome, valued, and included.
Where they can keep growing and look after their wellbeing.
So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent.
In the US, we also adhere to Affirmative Action principles.
This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles.
If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on ****** or 0808 234 4391.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels.
However, we have created a UK Recruitment FAQ guide.
Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive As you apply, we will ask you to share some personal information which is entirely voluntary.
We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions.
We would really appreciate it if you could take a few moments to complete it.
Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site.
All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.
The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK.
In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK.
GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment.
This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements.
For more information, please visit GSK's Transparency Reporting For the Record site.