Job Title A Protein Biochemist is required to join our Biologics Development team at Oxford Nanopore Technologies.
This role will focus on the development of new nanopore sequencing products, with a specific emphasis on improving the fundamental performance metrics of our platform.
About the Role This position will involve designing, purifying and analysing key protein components that form the backbone of our RNA and DNA sequencing chemistries, as well as any future nanopore sensing applications.
Responsibilities Carrying out expression and purification of protein variants aimed at improving the performance of our nanopore sensing applications Devising improvements to expression and purification methods to improve quality, yield and utility Characterisation of proteins using both classical biochemical techniques and using nanopore based single molecule assays Robust and thorough data analysis of any conducted experiments and accurate reporting to the wider team and division Design of improved protein variants through rational, structure-based design as well as more recent ML approaches Requirements Good understanding of the biochemical properties of proteins including DNA/RNA handling enzymes and/or membrane proteins Hands-on experience of recombinant protein expression from bacterial systems Experience in lab-scale purification of proteins using a variety of chromatographic methods with AKTA (or similar) purification systems Exposure to techniques for the biochemical/biophysical characterisation of purified proteins such as SDS-PAGE, LC-MS, EMSA, western blot or fluorescence-based activity assays What We Offer We offer an attractive salary (£50,000 - £60,000 per annum), generous pension contributions, private healthcare and an excellent working environment.
The successful candidate will also receive extensive training and mentorship to support their development.