Principal Scientist, Medicinal ChemistryCambridge, MA USA
What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?
Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.
Position Summary Quotient Tx is seeking a talented and highly motivated Principal Scientist, Medicinal Chemistry with relevant drug discovery experience to join our team. This is an exciting opportunity to design and execute medicinal chemistry strategies that will support biology validation and drug discovery from hit finding to lead generation, lead optimization and candidate selection. The successful candidate will work closely with Quotient's Leadership Team and scientists to rapidly advance drug discovery programs to IND and early clinical studies. They will be comfortable working in and contributing to a highly dynamic and cross-functional team environment. The ideal candidate must be independent, open-minded, goal-oriented, have excellent communication skills and work in a fast-paced entrepreneurial environment.
Key Responsibilities Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical developmentDefine, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization and candidate selectionProvide strategic, scientific, and managerial leadership to external CRO med chem teamsServe as project and chemistry lead for drug discovery programsCollaborate with the IP team to create and execute strategy to establish, protect and expand intellectual propertyCommunicate, collaborate, and coordinate effectively within cross-functional teamsEffectively present and communicate research findings at internal meetings and external scientific conferencesJob Qualifications Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industryExperienced in all aspects of medicinal chemistry including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selectionBroad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO) and computational chemistryWorking knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacologyExperience in managing and building strong relationships with chemistry CROsDemonstrated success in leading medicinal chemistry and projects teams to deliver high quality compounds into developmentExperience in oligonucleotide drug discovery is a plusTrack record of delivering on project and company goalsAbility to accommodate to rapidly changing priorities and deadlinesExcellent communication and project leadership skills and ability to work effectively in a cross-functional team settingProven track record for striving for a high level of innovation and scientific excellenceLocation: Cambridge, MA
About Flagship Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
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