Role Details Job Title: Principal Scientist Discovery Biology
Location: TRIMTECH therapeutics, The Milner Centre, Cambridge CB2 0AW, UK.
Salary: Competitive salary and benefits package, related to experience & qualifications
Overview TRIMTECH therapeutics, a rapidly growing well-funded and vibrant early-stage biotech based in Cambridge, UK, is expanding its team.
We are seeking a highly skilled and enthusiastic drug discovery scientist to support our efforts.
You will have a key role in assay biology, screening, and managing partner collaborations working closely with chemists and external advisors to create transformative new therapeutics.
Join our core team of experienced scientists and drug hunters to develop the next generation of protein degraders, based on the pioneering work of Dr. Leo James and Professor William McEwan (Science, 2024 and Cell, 2024).
Our mission is to create novel small molecule degraders of protein aggregates to combat neurodegenerative diseases and address some of society's biggest challenges.
We are seeking a highly skilled, enthusiastic and experienced drug discovery scientist to lead efforts developing and running assays both in the laboratory and with partners.
This role will include both laboratory work and management of CRO and partner efforts and bringing together these workflows.
If you are a passionate, experienced scientist looking to make a significant impact in the field of drug discovery, we encourage you to apply to join our dynamic team at TRIMTECH therapeutics.
You will be a key contributor to the development of groundbreaking treatments for neurodegenerative diseases.
Specification
Qualifications, Knowledge, and Experience Possess a BTEC, BSc, MSc, or PhD or comparable experience.
At least 5 years in an industrial setting, ideally within a CRO, biotech.
Hands on experience with high-throughput cellular and biochemical assay development, screening and transfer to other sites or partners.
Ability to work and manage externally partnered projects at CRO or academic partners.
A desire to develop drugs and learn new skills.
Essential Skills and Attributes Hands on experience with small molecule drug discovery projects.
Extensive experience with high throughput screening and automation.
Passion for science and a 'can-do' problem-solving approach.
Excellent interpersonal and communication skills.
Strong organizational skills, ability to prioritize work internally and at external partners.
Ability to work with other disciplines such as medicinal chemistry and DMPK experts.
Ability to develop new assays, SOPs, and transfer them to partners including CROs.
Desirable Skills and Attributes, one or more of these is desirable but not essential Expertise with iPSCs and/or neuronal models for drug discovery.
Experience developing protein degraders.
Expertise with protein aggregates and their role in disease.
Understanding of neurodegenerative disease biology.
To apply please send a cover letter and CV to