The Lead Genomics Data Scientist is an exciting new role designed to lead the development and implementation of a robust computational biology / bioinformatics strategy to meet the needs of Work-packages (WP) 1 & 2 (rapid Whole Genome Sequencing (WGS) and other omics & Myeloma multi-target next generation sequencing (NGS) panel) of the NHS Haemato-oncology Genomic Network of Excellence (NoE). Duties of this post will encompass bioinformatic, analytical and administrative activities in addition to national educational and engagement roles.
Main duties of the job Design, develop, implement and take through ISO15189 accreditation: an appropriate bioinformatics pipeline for the analysis of all variant types for a tumour-only Next Generation Sequencing panel for plasma cell dyscrasias. appropriate bioinformatic pipeline(s) for the analysis of all variant types from tumour-only and tumour: matched germline Whole Genome Sequencing for a range of different haematological malignancies. Work with other Genomic Laboratory Hubs (GLHs) on the national implementation of the tumour-only Next Generation Sequencing panel for plasma cell dyscrasias, by designing and implementing appropriate engagement and education programmes around the bioinformatics and interpretation and analysis components of the panel. Work with other stakeholders nationally including Genomics England and NHS England's Genomics Unit in the design, development and implementation of a strategy and mechanism for local WGS with central bioinformatics pipeline provision and local clinical interpretation and reporting. Design, develop and implement the necessary analysis tools for other 'omics' which may include but not be limited to short read RNA sequencing / whole transcriptome sequencing, long read WGS and hybrid long read WGS and targeted sequencing assays. About us Oxford University Hospitals NHS Foundation Trust is one of the largest NHS teaching trusts in the country. It provides a wide range of general and specialist clinical services and is a base for medical education, training and research. The Trust comprises four hospitals - the John Radcliffe Hospital, Churchill Hospital and Nuffield Orthopaedic Centre in Headington and the Horton General Hospital in Banbury.
Our values, standards and behaviours define the quality of clinical care we offer and the professional relationships we make with our patients, colleagues and the wider community.
We call this Delivering Compassionate Excellence and its focus is on our values of compassion, respect, learning, delivery, improvement and excellence. Job description Job responsibilities Main duties and responsibilities of the post Leadership and Management Develop and implement a computational biology / bioinformatics strategy to allow the success of WPs 1 & 2 of the NHS Haemato-oncology Genomic Network of Excellence. Implementation of WPs 1 & 2 on a national level will require the post-holder to be able to absorb and disseminate highly complex information around the bioinformatics pipelines to both specialist and non-specialist audiences. Work with NHS Genomics Unit (national oversight group) to ensure alignment with their vision for the future of genomics within the Genomic Medicine Service (GMS). Assist in the national adoption of WP2 where desired by other GLHs. Develop a practical and affordable strategy around data-storage for the WPs 1 & 2 in the NoE which includes collaboration with third party suppliers. Clinical/Scientific Lead the development, implementation, population, maintenance, validation/verification and utilisation of NGS analysis software and databases. Oversee the development of bioinformatics pipelines for NoE WPs 1 & 2 to nationally accepted Standards (UKAS or equivalent). Take responsibility for the review, validation/verification and implementation of highly complex bioinformatic software, tools and applications. Collaborate with other stakeholders to identify opportunities for improving genomic services. Data Management / Clinical Governance Plan, manage and organise own workload to meet priorities and ensure timely completion. Maintain responsibility for writing, updating, and communicating Standard Operating Procedures. Ensure the accuracy and timeliness of all patient results related to the NoE WPs 1 & 2. Innovation, research, and development Undertake planned and agreed research and service developments relevant to NoE WPs 1 & 2. Maintain up to date knowledge of developments and research in the field of expertise. Education and Training Design and implement the necessary national training programmes around the NoE WPs 1 & 2 national implementation. Professional To maintain, or be actively working towards, State Registration with HCPC. Participate in regular performance review and personal development planning. Person Specification Qualifications & Training Essential PhD level education which includes a substantial component of genomic analysis. Desirable Professional registration with HCPC. Experience Essential Significant experience of developing and implementing pipelines in clinical, academic or industry settings. Desirable Experience of working in genomics analysis at the research / clinical interface. Skills & Knowledge Essential Excellent skills in coding / programming, mathematical modelling, database construction. Desirable In depth knowledge of the biology of plasma cell dyscrasias. Abilities Essential Ability to communicate complex bioinformatic, scientific and confidential information. Desirable Ability to manage conflict. Employer details Employer name Oxford University Hospitals NHS Foundation
#J-18808-Ljbffr